Rechtsmedizinische erkentnisse zum waterhousefriderichsen. A condition developed due to failure of adrenal gland, caused by bleeding into the adrenal glands. Waterhousefriderichsen syndrome wfs is a collection of symptoms resulting from the failure of the adrenal glands to function normally as a result of bleeding into the gland. Wfs is reported to occur in splenectomized patients, and in patients with congenital asplenia or decreased splenic function 25. In those patients with a risk factor for adrenal hemorrhage, clinicians should keep their mind broad and open, especially when the hypotension does not respond to vasopressor alone. Waterhousefriderichsen syndrome, a complication of acute bacterial meningitis, is associated with severe disseminated intravasal coagulopathy and adrenocortical insufficiency. The word syndrome comes from the greek word sundrom, which means concurrence of symptoms, or from word sundromos, which means running together. The adrenal glands produce and release different hormones that the body. It is usually caused by severe meningococcal infection or other severe, bacterial infection. Pdf waterhousefriderichsen syndrome is one of the fatal complications of meningococcal infection. It is characterized by overwhelming bacterial infection meningococcemia. Fatal waterhousefriderichsen syndrome due to ewingella. The waterhousefriderichsen syndrome wfs is associated with some infectious diseases leading to substantial morbidity by producing acute adrenal insufficiency associated with hemorrhage and dysfunction of the suprarenal glands, at a time when their response is crucial to address acute stress table 16.
The waterhousefriderichsen syndrome wfs is the morphological. The patient died suddenly within 14 hours after presentation. All structured data from the file and property namespaces is available under the creative commons cc0 license. A fatal case of waterhousefriderichsen syndrome resulting from ewingella americana infection in a previously healthy 74yearold woman is reported. The disease now known as the waterhousefriderichsen syndrome was recognized as an entity by little1 in 1901. Waterhouse friderichsen syndrome waterhousefriderichsen. Most patients with this condition are children, although adults may rarely be affected. Plotzlicher tod bei waterhousefriderichsensyndrom im. Waterhousefriderichsen syndrome wfs is an emergency condition, characterized by fever, cyanosis, bruises, andor shock. The presenting clinical picture is frequently pharyngitis, fever, and. The waterhousefriderichsen syndrome is a clinical entity first described in 1911 by waterhouse1 in an eightmonthold child. Files are available under licenses specified on their description page. Typically it is caused by neisseria meningitidis the bacterial infection leads to massive bleeding into one or usually both adrenal glands.
Alternative names fulminant meningococcemia waterhousefriderichsen syndrome. Waterhousefriderichsen syndrome synonyms, waterhousefriderichsen syndrome pronunciation, waterhousefriderichsen syndrome translation, english dictionary definition of waterhousefriderichsen syndrome. Adrenal hemorrhage has been associated with meningococcemia waterhousefriderichsen syndrome, but pseudomonas aeruginosa was the most common pathogen in one report of 51 children clinical manifestations of adrenal insufficiency in adults view in chinese. We, therefore, report a case of waterhousefriderichsen syndrome resulting from an invasive pneumococcal infection in a patient with a hypoplastic spleen. Waterhousefriderichsen syndrome information mount sinai. Waterhouse friderichsen syndrome, shock, adrenal insuf. Waterhousefriderichsen syndrome wfs is defined as adrenal gland failure due to bleeding into the adrenal glands, commonly caused by severe bacterial infection. Causes the adrenal glands are 2 triangleshaped glands. Waterhousefriderichsen syndrome wfs is a group of symptoms resulting from the failure of the adrenal glands to function normally as a result of bleeding into the gland. The syndrome is most common in children under five and may last only a few hours.
Waterhousefriderichsen syndrome multimedia encyclopedia. Waterhousefriderichsen syndrome, shock, adrenal insuf. The disease known as the waterhousefriderichsen syndrome was described as an entity by graham little 1 in 1901. If you have problems viewing pdf files, download the latest version of adobe reader. Waterhousefriderichsen syndrome is one of the fatal complications of meningococcal infection. In response to acute stress, adrenal changes result in. Fulminant meningococcal sepsis waterhousefriderichsen syndrome. Septic shock caused by waterhousefriderichsen syndrome. Here we report a fatal case of this syndrome due to neisseria meningitidis in a 29yearold male patient who was admitted with highgrade fever and chills and vomiting since 7 days, a skin rash over the abdomen and trunk, and altered sensorium since 2 days. The question arose whether there are prehospital strategies to positively affect this special form of sepsis or whether there are opportunities to. The bacterial infection leads to massive bleeding into one or both adrenal glands.
Pdf waterhousefriderichsen syndrome in an adult patient with. Waterhousefriderichsen syndrome statpearls ncbi bookshelf. Typically, it is caused by neisseria meningitidis the bacterial infection leads to massive bleeding into one or usually both adrenal glands. He gave an accurate description of symptomatology and pathology. Septic shock caused by neisseria meningitidis infection, defined as waterhousefriderichsen syndrome in 1946, has a high mortality rate of between 21% and 44%. Waterhousefriderichsen syndrome radiology reference. Waterhousefriderichsen syndrome pathology britannica. Neisseria meningitidis cause a fulminating fatal infection, frequently with few or no signs or preconditions. Post the definition of waterhousefriderichsen syndrome to facebook share the definition of waterhousefriderichsen syndrome on twitter. Meningococcemia is a lifethreatening infection that occurs when the bacteria neisseria meningitidis invades the. Waterhouse friderichsen syndrome is defined as adrenal gland failure due to bleeding into the adrenal glands, commonly caused by severe bacterial infection. Erste gabe 15 minuten vor oder gleichzeitig mit erster antibiotikagabe.
Meningokokkensepsis mit nebennierenbeteiligung waterhouse. A case of waterhousefriderichsen syndrome resulting from. Waterhouse friderichsen syndrome is a rare condition that presents with nonspecific symptoms and requires the efforts of an interprofessional healthcare team. Medical definition of waterhousefriderichsen syndrome. The condition is most frequently seen in children younger than 10 years old. Pdf first case reported in adults waterhousefriderichsen syndrome secondary to staphylococcus haemolyticus is concluded find, read and cite all the research you need on researchgate. Symptoms include acute adrenal gland insufficiency, and profound shock. Schwere sepsis im kindesalter am beispiel des waterhouse.
Waterhousefriderichsen syndrome, a rare type of septicemia blood poisoning of rapid and severe onset, marked by fever, collapse and sometimes coma, hemorrhage from skin and mucous membranes, and severe bilateral hemorrhage of the adrenal cortical tissue. Waterhousefriderichsen syndrome also known as purpura fulminans 9 or hemorrhagic adrenalitis 10 is characterized by adrenal insufficiency that results from atraumatic adrenal hemorrhage in consequence of septicemia. Pdf first case reported in adults waterhousefriderichsen syndrome secondary to staphylococcus haemolyticus is concluded. Here, we report a rare case of wfs, presenting with purpura fulminans, resulting from an. Waterhousefriderichsen syndrome penn state hershey. Definition waterhousefriderichsen syndrome wfs or hemorrhagic adrenalitis or fulminant meningococcemia, is defined as adrenal gland failure due to bleeding into the adrenal glands, caused by severe bacterial infection most commonly the meningococcus neisseria meningitidis. Waterhousefriderichsen syndrome infectious disease a clinical crisis characterized by acute adrenal insufficiency, often accompanied by septicemia. Abstract the waterhousefriderichsen syndrome wfs is the maximum form of a peracute meningococcal sep sis. It is characterized by overwhelming bacterial infection meningococcemia leading to massive blood invasion, organ failure, coma, low blood pressure and shock, disseminated intravascular coagulation with. Despite modern intensive medical care including sophisticated pharmacotherapy the mortality is still high. The diagnosis of waterhousefriderichsen syndrome as the cause of death was established post mortem based on autopsy findings, microscopic examination. Dem waterhousefriderichsensyndrom liegt als pathogenetisches.332 703 1081 394 320 108 1230 238 811 554 1129 521 641 586 1362 1215 107 756 1545 936 1611 983 1579 260 880 142 234 252 966 263 661